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Gastroesophageal Reflux Disease (GERD, or GORD when -oesophageal, the BE form, is substituted) is injury to the esophagus that develops from chronic exposure of the esophagus to acid coming up from the stomach (reflux). In contrast, heartburn is the symptom of acid in the esophagus, characterized by a burning discomfort behind the breastbone (sternum). ...

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GERD Essentials
By Michael Sanford
GERD stands for gastroesophageal reflux disease, a clinical condition that occurs when reflux of stomach acid into the esophagus is severe enough to impact the patient’s life and/or damage the esophagus. Gastroesophageal refers to the stomach and esophagus while reflux means to flow back or return. You see, when chewed-up food slides down the esophagus or swallowing tube, and into the stomach, there digestive juices begin to break down the food. A special type of muscle called a sphincter connects the esophagus and the stomach. The sphincter works like a gate. It opens up so food can get into the stomach, and then it closes again. This keeps the food and acidic stomach juices from flowing back into the esophagus. However, if the sphincter is weak or opens at the wrong time, there's a problem. Whatever's in the stomach goes the wrong way, which is back up into the esophagus. And because what's in the stomach is high in acid, this can irritate the esophagus. This condition is then called reflux.

GERD affects at least an estimated 5% to 7% of the global population. GERD is most common in adults over age 40 but virtually anyone can get GERD, even infants. Persistent heartburn is the most frequent symptom of GERD. It is an uncomfortable burning sensation behind the breastbone, most commonly occurring after a meal. This condition has nothing to do with the heart, but everything to do with the stomach and the esophagus. Eating too much and going to bed in a very full stomach can cause heartburn in a lot of people. The difference between GERD and heartburn is that GERD is a disease and heartburn is its most common symptom. Almost everyone has experienced heartburn. About 25 million American adults suffer daily from heartburn. Someone who experiences recurring, significant heartburn two or more times a week may have GERD. Frequent heartburn that disrupts one's lifestyle suggests the diagnosis of GERD. Another symptom of GERD is regurgitation. It is a sensation of acid backed up in the esophagus.

Early diagnosis of GERD is important to avoid complications in the future. A physician can usually make an easy diagnosis of GERD if the patient finds relief from persistent heartburn and acid regurgitation after taking antacids for short periods. Laboratory or more invasive tests, including endoscopy, barium-swallow radiograph, PH monitor examination, and manometry may be required if the diagnosis is

New Genetic Markers For Ulcerative Colitis Identified, Researchers Report In Nature Genetics
An international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature Genetics

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